Nucleotide sequence of the Saccharomyces cerevisiae CLN1 and CLN2 genes

The Saccharomyces cerevisiae CLNJ and CLN2 genes were S.I.R. from the National Institute of General Medical Sciences. isolated as high-dosage suppressors of a temperature-sensitive S.I.R. also acknowledges support from American Cancer Society mutation of the CDC28 gene, which encodes a protein kinase Faculty Research Award FRA-248. required for cell division. The CLNJ and CLN2 genes encode proteins that share significant homology to cyclins and are involved in the control of the G1-S transition of the cell cycle REFERENCES (1, 2). Shown below is the nucleotide sequence of genomic DNA 1. Hadwiger,J.A., Wittenberg,C., Richardson,H.E., De Barros Lopes,M. and fragments which contain the open reading frame of the CLNJ Reed,S.I. (1989) Proc. Natl. Acad. Sci. USA 86, 6255-6259. (334-1971) and CLN2 (346-1980) genes. 2. Richardson,H.E., Wittenberg,C., Cross,F. and Reed,S.I. (1989) Cell, 59, (334-1971) ~~~~~~~~~~~~~1127-1133. ACKNOWLEDGEMENTS